Hydrochloric Acid → HCID 18187684, compound

HRID 1357956Notes

Reaction equation

HRID 1357956 reaction equation
[CH2:1]([C:8]1[CH:12]=[C:11](N2CCCCC2)[N:10]([CH2:19][CH3:20])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:21].[C:22]([Cl:25])(=O)[CH3:23]>CO>[ClH:25].[ClH:21].[CH2:1]([C:8]1[CH:12]=[C:11]([CH:23]2[CH2:22][CH2:19][NH:10][CH2:11][CH2:12]2)[N:10]([CH2:19][CH3:20])[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 21193146HCID 21193146, compound

Product 1

HCID 18187684HCID 18187684, compoundYield 199.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(t-Butoxycarbonyl)4-(3-benzyl-1-ethyl-(1H)-pyrazol-5-ylpiperidine 5 from Step D (18.5 g, 50 mmol) was added to a solution of HCl (530 mmol) in methanol (300 mL) prepared by the slow addition of acetyl chloride (38 mL, 530 mmol) and aged for 90 min. The reaction was stirred at rt for 16 h and then evaporated to dryness to afford 17.1 g (100%) of the title compound as a hygroscopic white solid.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-d3103e6ec4634c30b6a501c94aa948e3
Source dataset
uspto-grants-2003_07
Patent number
US06593346B2

Reaction notes

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