Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1) → HCID 12070124, compound

HRID 1357991Notes

Reaction equation

HRID 1357991 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][CH3:19])[CH:14]=3)[CH:9]2[CH2:20][C:21]2[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=2)=[CH:4][CH:3]=1.Cl.Cl[CH2:30][CH2:31][CH:32]1[CH2:36][CH2:35][CH2:34][N:33]1[CH3:37]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:18][CH3:19])[CH:14]=3)[CH:9]2[CH2:20][C:21]2[CH:22]=[CH:23][C:24]([O:27][CH2:30][CH2:31][CH:32]3[CH2:36][CH2:35][CH2:34][N:33]3[CH3:37])=[CH:25][CH:26]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3017050Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1)HCID 12070121HCID 12070121, compound

Product 1

HCID 12070124HCID 12070124, compoundYield 45%

Procedure

The title compound was prepared as described in Example 3.D, using 2-(4-fluorophenyl)-1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline (0.13 g, 0.36 mmol) and 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (0.079 g, 0.429 mmol) to provide the title compound (0.076 g, 45% yield): ES-MS (m/z) 475 [M+H]+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-a2d5d6e6237b4d3abc254ae40e3c905b
Source dataset
uspto-grants-2003_07
Patent number
US06593322B1

Reaction notes

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