HCID 12085084, compound → HCID 12085085, compound

HRID 1358112Notes

Reaction equation

HRID 1358112 reaction equation
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]2[C:8]3[C:16]([O:17][CH:18]([F:20])[F:19])=[CH:15][CH:14]=[CH:13][C:9]=3[O:10][C:11](=[O:12])[C:6]=2[CH:5]=1)([O-])=O>[Pd].O1CCOCC1>[NH2:1][C:4]1[CH:22]=[CH:21][C:7]2[C:8]3[C:16]([O:17][CH:18]([F:20])[F:19])=[CH:15][CH:14]=[CH:13][C:9]=3[O:10][C:11](=[O:12])[C:6]=2[CH:5]=1

Participants

4

Reactant 1

HCID 12085084HCID 12085084, compound

Product 1

HCID 12085085HCID 12085085, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

The solution of Example 4A (6.56 g.) was suspended in. dioxane (250 mL) and hydrogenated over 10% Pd/C at 4 atmospheres H2 at 50° for 3 hours. The solvent was removed under reduced pressure, diethylether was and the resulting solid filtered to provide the titled compound (5.55 g, 94%).

Workup

  1. customThe solvent was removed under reduced pressure, diethylether
  2. filtrationthe resulting solid filtered

Sources & evidence

ORD record
ord-374cc0240b694972b8f6c60989071e44
Source dataset
uspto-grants-2003_07
Patent number
US06593480B2

Reaction notes

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