反应详情

The compound of Example 5D (4.84, 13.31 mmol) in ethanol (45 mL) was heated at 65° C. with NaBH4(2.03 g, 53.42 mmol). After 1 hour Chloroform and aqueous NaCl was added. The organic phase was separated, washed with aqueous KHCO3, dried (Na2SO4), filtered and the solvent removed under reduced pressure to provide the titled compound (3.844 g, 80%).

1. customThe organic phase was separated
2. washwashed with aqueous KHCO3
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customthe solvent removed under reduced pressure