HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → 4-Amino-2(alpha-hydroxybenzyl)-2'-methoxymethoxy-6'-methoxy-biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-Amino-2-benzoyl-2'-methoxymethoxy-6'-methoxy-biphenyl | HCID 18188557 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-2(alpha-hydroxybenzyl)-2'-methoxymethoxy-6'-methoxy-biphenyl | HCID 18189195 | 80% |
Reaction Steps
The compound of Example 5D (4.84, 13.31 mmol) in ethanol (45 mL) was heated at 65° C. with NaBH4(2.03 g, 53.42 mmol). After 1 hour Chloroform and aqueous NaCl was added. The organic phase was separated, washed with aqueous KHCO3, dried (Na2SO4), filtered and the solvent removed under reduced pressure to provide the titled compound (3.844 g, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06593480B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-cac13647593b46009d3c748982c29a73 |
| Source note | uspto-grants-2003_07 |