2-Methylbenzenesulfonic acid → HCID 18504111, compound

HRID 1358136Notes

Reaction equation

HRID 1358136 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]1[CH:30]=[CH:29][C:15]2[C:16]3[C:24]([O:25][CH:26]([F:28])[F:27])=[CH:23][CH:22]=[CH:21][C:17]=3[O:18][CH:19]([OH:20])[C:14]=2[C:13]=1[Br:31])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:32]1(C)C(S(O)(=O)=O)=CC=CC=1>CO>[Br:31][C:13]1[C:14]2[CH:19]([O:20][CH3:32])[O:18][C:17]3[C:16]([C:15]=2[CH:29]=[CH:30][C:12]=1[NH:11][C:9](=[O:10])[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[C:24]([O:25][CH:26]([F:28])[F:27])[CH:23]=[CH:22][CH:21]=3

Participants

4

Reactant 2

HCID 69252-Methylbenzenesulfonic acidHCID 18188678HCID 18188678, compound

Product 1

HCID 18504111HCID 18504111, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Example 27E (4.1 g, 8.3 mmol) and toluenesulfonic acid (1 g, 5.2 mmol) in methanol (100 mL) was stirred for 1 hour, and reduced in volume under reduced pressure. The solid was then collected by filtration to provide the titled compound. MS(ESI(−)Q1MS) m/z 504 and 506 (M−H)−.

Workup

  1. filtrationThe solid was then collected by filtration

Sources & evidence

ORD record
ord-112309af8c7646b3bbb5dc2dcc2471b0
Source dataset
uspto-grants-2003_07
Patent number
US06593480B2

Reaction notes

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