2-Nitropropane → HCID 21951129, compound

HRID 1358169Notes

Reaction equation

HRID 1358169 reaction equation
[N+:1]([CH:4]([CH3:6])[CH3:5])([O-:3])=[O:2].[CH2:7]([CH2:9][NH2:10])[OH:8].[CH2:11]=O.[OH-].[Na+]>C(O)(C)C.O>[N+:1]([C:4]([CH3:11])([CH3:6])[CH2:5][NH:10][CH2:9][CH2:7][OH:8])([O-:3])=[O:2]

Participants

7

Reactant 4

HCID 3982-NitropropaneHCID 700EthanolamineHCID 712FormaldehydeHCID 14798Sodium Hydroxide

Product 1

HCID 21951129HCID 21951129, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

607.8 g (6.55 mol) of 2-nitropropane and 100 ml of water are added to a solution of 450 g (7.40 mol) of ethanolamine in 1000 ml of isopropanol. The solution is stirred at room temperature and 225.4 g (7.5 mol) of paraformaldehyde and 7 ml of 20% aqueous solution of sodium hydroxide (% w/v) are added under stirring and maintaining the temperature at room temperature for 16 hours. The mixture is then heated to 50° C. with nitrogen being bubbled into the mixture to eliminate the formaldehyde in excess. The mixture obtained is used for the following reaction without any isolation of the product.

Workup

  1. stirringunder stirring
  2. temperaturemaintaining the temperature at room temperature for 16 hours
  3. temperatureThe mixture is then heated to 50° C. with nitrogen being
  4. custombubbled into the mixture
  5. customThe mixture obtained
  6. customis used for the following reaction without any isolation of the product

Sources & evidence

ORD record
ord-b1e94eb294f54523abfebd5c8cc6888a
Source dataset
uspto-grants-2003_07
Patent number
US06596461B1

Reaction notes

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