2-Thiophenesulfonyl chloride → Benzenesulfonamide

HRID 1358332Notes

Reaction equation

HRID 1358332 reaction equation
C([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14]C2C(C3C=CC=CC=3)=C(OCCN)N=C(SC)N=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)(C)(C)C.S1C=CC=C1S(Cl)(=O)=O>>[C:8]1([S:11]([NH2:14])(=[O:13])=[O:12])[CH:9]=[CH:10][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 855182-Thiophenesulfonyl chlorideHCID 181841994-tert.-butyl-N-[6-(2-aminoethoxy)-2-methylsulfanyl-5-phenyl-pyrimidin-4-yl]-benzenesulfonamide

Product 1

HCID 7370Benzenesulfonamide

Procedure

According to Example 4a) 100 mg 4-tert.-butyl-N-[6-(2-aminoethoxy)-2-methylsulfanyl-5-phenyl-pyrimidin-4-yl]-benzenesulfonamide was reacted with 121 mg thiophene-2-sulfonylchloride to give 115 mg 4-tert.-butyl-N-[6-(2-(2-thiophenesulfonyl)-amino)-ethoxy)-2-methylsulfanyl-5-phenyl-pydmidin-4-yl]-benzenesulfonamide. LC-MS: tR=5.98 min, [M−1]−=617.39.

Sources & evidence

ORD record
ord-d952e8771bac412999289a73e34b41d0
Source dataset
uspto-grants-2003_07
Patent number
US06596719B1

Reaction notes

Loading…