4,6-Dichloro-2-cyclopropyl-5-(o-methoxyphenoxy)-pyrimidine → HCID 18184173, compound

HRID 1358338Notes

Reaction equation

Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH3:16])=[C:6]([Cl:17])[N:5]=[C:4]([CH:18]2[CH2:20][CH2:19]2)[N:3]=1.[K].[CH:22]([C:25]1[CH:26]=[CH:27][C:28]([S:31]([NH2:34])(=[O:33])=[O:32])=[N:29][CH:30]=1)([CH3:24])[CH3:23]>>[CH:22]([C:25]1[CH:26]=[CH:27][C:28]([S:31]([NH:34][C:2]2[C:7]([O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[O:15][CH3:16])=[C:6]([Cl:17])[N:5]=[C:4]([CH:18]3[CH2:20][CH2:19]3)[N:3]=2)(=[O:33])=[O:32])=[N:29][CH:30]=1)([CH3:24])[CH3:23]

Participants

Reactant 2

HCID 219795624,6-Dichloro-2-cyclopropyl-5-(o-methoxyphenoxy)-pyrimidine

HCID 69289451179400-19-2

Product 1

HCID 18184173HCID 18184173, compound

Procedure

According to the procedure described in Example 1g) 3.3 g 4,6-dichloro-2-cyclopropyl-5-(o-methoxyphenoxy)-pyrimidine (prepared according to procedures described in Example 1) was reacted with 5-i-propyl-2-pyridyl-sulfonamide potassium salt to give 4.04 g 5-i-propyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-pyridine-2-sulfonamide. LC-MS: tR=5.64 min, [M−1]−=473.29.

Sources & evidence

ORD record: ord-e5178cae43e247fcad1a0f9b15f76efe
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06596719B1

Reaction notes

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