4-Toluenesulfonyl chloride → HCID 9873255, compound

HRID 1358340Notes

Reaction equation

HRID 1358340 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH:13][C:14]2[C:19]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH3:28])=[C:18]([O:29][CH2:30][CH2:31][NH2:32])[N:17]=[C:16]([CH:33]3[CH2:35][CH2:34]3)[N:15]=2)(=[O:12])=[O:11])=[N:8][CH:9]=1)([CH3:3])[CH3:2].CC1C=C[C:40]([S:43](Cl)(=[O:45])=[O:44])=[CH:39]C=1>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH:13][C:14]2[C:19]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH3:28])=[C:18]([O:29][CH2:30][CH2:31][NH:32][S:43]([CH2:40][CH3:39])(=[O:45])=[O:44])[N:17]=[C:16]([CH:33]3[CH2:34][CH2:35]3)[N:15]=2)(=[O:12])=[O:11])=[N:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 181842365-i-propyl-N-[6-(2-aminoethoxy)-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-pyridine-2-sulfonamide

Product 1

HCID 9873255HCID 9873255, compound

Procedure

According to the procedure described in Example 4a), 250 mg 5-i-propyl-N-[6-(2-aminoethoxy)-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-pyridine-2-sulfonamide was reacted with 4-methylbenzenesulfonylchloride to give 100 mg 5-i-propyl-N-[6-(2-ethanesulfonylamino-ethoxy)-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-pyridine-2-sulfonamide. LC-MS: tR=5.32 min, [M−1]−=604.39.

Sources & evidence

ORD record
ord-97d615449a414906bb54b419cf9a9466
Source dataset
uspto-grants-2003_07
Patent number
US06596719B1

Reaction notes

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