2-Thiophenesulfonyl chloride → HCID 18184216, compound

HRID 1358346Notes

Reaction equation

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[C:20]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])=[C:19]([O:30][CH2:31][CH2:32][NH2:33])[N:18]=[C:17]([C:34]3[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=3)[N:16]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[S:40]1[CH:44]=[CH:43][CH:42]=[C:41]1[S:45](Cl)(=[O:47])=[O:46]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([NH:14][C:15]2[C:20]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])=[C:19]([O:30][CH2:31][CH2:32][NH:33][S:45]([C:41]3[S:40][CH:44]=[CH:43][CH:42]=3)(=[O:47])=[O:46])[N:18]=[C:17]([C:34]3[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=3)[N:16]=2)(=[O:13])=[O:12])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 855182-Thiophenesulfonyl chloride

HCID 18184204HCID 18184204, compound

Product 1

HCID 18184216HCID 18184216, compound

Procedure

According to the procedure described in Example 4a) 20 mg 4-tert.-butyl-N-[6-(2-aminoethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-benzene-sulfonamide was reacted with thiophene-2-sulfonylchloride to give 20 mg 4-tert.-butyl-N-[6-(2-(thiophene-2-sulfonylamino)-ethoxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-benzene-sulfonamide. LC-MS: tR=5.17 min, [M+1]+=696.57.

Sources & evidence

ORD record: ord-c0571cc0659544d3bea4f725caf04f25
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06596719B1

Reaction notes

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