2,2-Diphenylacetyl chloride → N-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-2,2-diphenyl-acetamide

HRID 1358440Notes

Reaction equation

HRID 1358440 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:17]1([CH2:20][C:21]2[O:25][C:24]([NH2:26])=[N:23][N:22]=2)[CH2:19][CH2:18]1>>[CH:17]1([CH2:20][C:21]2[O:25][C:24]([NH:26][C:8](=[O:9])[CH:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[N:23][N:22]=2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 226610775-(Cyclopropylmethyl)-1,3,4-oxadiazol-2-amine

Product 1

HCID 22661048N-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-2,2-diphenyl-acetamide

Procedure

The title compound, white solid, m.p. 158-159° C. and MS: m/e=334.3 (M+H+) was prepared in accordance with the general method of example 44a from 2,2-diphenylacetic acid chloride and 5-cyclopropylmethyl-[1,3,4]oxadiazol-2-ylamine.

Sources & evidence

ORD record
ord-5e10c4a7cc6f47deaa365e521cde0441
Source dataset
uspto-grants-2003_07
Patent number
US06596743B2

Reaction notes

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