Oxalyl chloride → (3,5-Dibromo-4-methoxyphenyl)acetylchloride

HRID 1358458Notes

Reaction equation

HRID 1358458 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=O)[CH:5]=[C:6]([Br:10])[C:7]=1[O:8][CH3:9].C(Cl)(=O)C([Cl:18])=O>C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([Cl:18])=[O:14])[CH:5]=[C:6]([Br:10])[C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 107347342-(3,5-Dibromo-4-Methoxyphenyl)Acetic Acid

Product 1

HCID 18184515(3,5-Dibromo-4-methoxyphenyl)acetylchlorideYield 100%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 3,5-dibromo-4-methoxy-phenylacetic acid (30.29 g, 0.093 mol) and oxalyl chloride (118.7 g, 81.6 ml, 0.93 mol) in 300 mL of benzene was refluxed for 6 h. The solution was evaporated with benzene 3 times and dried in vacuum. Yield 100%.

Workup

  1. customThe solution was evaporated with benzene 3 times
  2. customdried in vacuum

Sources & evidence

ORD record
ord-1db04d3d36354ae2a34269c50c3b7c8c
Source dataset
uspto-grants-2003_07
Patent number
US06596734B1

Reaction notes

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