Oxalyl chloride → (3,5-Dibromo-4-methoxyphenyl)acetylchloride

HRID 1358471Notes

Reaction equation

HRID 1358471 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=O)[CH:5]=[C:6]([Br:10])[C:7]=1[O:8][CH3:9].C(Cl)(=O)C([Cl:18])=O>C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([Cl:18])=[O:14])[CH:5]=[C:6]([Br:10])[C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 107347342-(3,5-Dibromo-4-Methoxyphenyl)Acetic Acid

Product 1

HCID 18184515(3,5-Dibromo-4-methoxyphenyl)acetylchloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3,5-Dibromo-4-methoxyphenyl acetic acid (3.239 g, 0.01 mol) was refluxed with oxalyl chloride (2.03 g, 0.016 mol) in anhydrous benzene (50 mL) for 6 h. The reaction mixture was cooled, concentrated and evaporated 3 times with benzene to give an oil which was used for further reaction.

Workup

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. customevaporated 3 times with benzene
  4. customto give an oil which
  5. customwas used for further reaction

Sources & evidence

ORD record
ord-f40e8dfb090a4d0ab319ddc7b87fad7f
Source dataset
uspto-grants-2003_07
Patent number
US06596734B1

Reaction notes

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