Sodium Hydroxide → HCID 9809980, compound

HRID 1358563Notes

Reaction equation

HRID 1358563 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([S:16][C:17]2[CH:18]=[CH:19][C:20]3[N:24]=[C:23]([CH2:25][O:26][C:27]4[CH:32]=[CH:31][C:30]([CH2:33][CH:34]([O:39][CH2:40][C:41]5[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=5)[C:35]([O:37]C)=[O:36])=[CH:29][CH:28]=4)[N:22]([CH3:48])[C:21]=3[CH:49]=2)[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:5]1[CH:6]=[C:7]([S:16][C:17]2[CH:18]=[CH:19][C:20]3[N:24]=[C:23]([CH2:25][O:26][C:27]4[CH:32]=[CH:31][C:30]([CH2:33][CH:34]([O:39][CH2:40][C:41]5[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=5)[C:35]([OH:37])=[O:36])=[CH:29][CH:28]=4)[N:22]([CH3:48])[C:21]=3[CH:49]=2)[CH:8]=[C:9]([C:12]([CH3:14])([CH3:15])[CH3:13])[C:10]=1[OH:11])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9896275HCID 9896275, compound

Product 1

HCID 9809980HCID 9809980, compoundYield 60.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Reaction and isolation were conducted in a similar procedure to that described in Example 2 using methyl 3-[4-[6-(3,5-di-t-butyl4-hydroxyphenylthio)-1-methyl-1H-benzimidazol-2-ylmethoxy]phenyl]-2-(4-fluorobenzyloxy)propionate (0.22 g), aqueous 2N sodium hydroxide solution (2 ml) and methanol (5 ml) to afford the title compound (0.13 g, mp 40-46° C.).

Workup

  1. customReaction and isolation

Sources & evidence

ORD record
ord-808b9a0870944ed796b3defabaf88224
Source dataset
uspto-grants-2003_07
Patent number
US06596751B2

Reaction notes

Loading…