Hydrochloric Acid → HCID 69871513, compound

HRID 1358565Notes

Reaction equation

HRID 1358565 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:27])([OH:26])[C:22]([O:24]C)=[O:23])=[CH:17][CH:16]=1.Cl>O1CCOCC1>[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:27])([OH:26])[C:22]([OH:24])=[O:23])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69871301HCID 69871301, compound

Product 1

HCID 69871513HCID 69871513, compoundYield 103.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of methyl 4-(1-methyl-6-methoxy-1H-benzimidazol-2-ylmethoxy)phenyllactate (0.15 g), concentrated hydrochloric acid (2 ml) and dioxane (2 ml) was heated at reflux for 3 hours. The reaction mixture was concentrated and the water of the residue was removed by azeotropic distillation in dioxane and the crystals were isolated by filtration to afford the title compound (0.15 g, mp 216-218° C.).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3 hours
  3. concentrationThe reaction mixture was concentrated
  4. customthe water of the residue was removed by azeotropic distillation in dioxane
  5. customthe crystals were isolated by filtration

Sources & evidence

ORD record
ord-f4d4564254a442c79fcfeadf9d7a6ae9
Source dataset
uspto-grants-2003_07
Patent number
US06596751B2

Reaction notes

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