HCID 18185371, compound → HCID 18185373, compound

HRID 1358605Notes

Reaction equation

HRID 1358605 reaction equation
[C:1]([C:9]1[CH:14]=[C:13]([N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)[CH:12]=[CH:11][C:10]=1[NH:22]C(=O)C(C)(C)C)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl>[NH2:22][C:10]1[CH:11]=[CH:12][C:13]([N:15]2[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]2)=[CH:14][C:9]=1[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:8]

Participants

3

Reactant 1

HCID 18185371HCID 18185371, compound

Product 1

HCID 18185373HCID 18185373, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 0.3 g (0.8 mmol) of N-[2-benzoyl-4-(4-methyl-piperazin-1-yl)-phenyl]-2,2-dimethyl-propionamide in 10 ml of 3 N aqueous hydrochloric acid was stirred for 20 h at room temperature. The reaction mixture was extracted once with ethyl acetate, the aqueous layer was made alkaline with concentrated sodium hydroxide solution and was extracted four times with dichloromethane. The combined organic layers were dried over magnesium sulfate and evaporated to yield 245 mg (quantitative) of the product as light yellow oil.

Workup

  1. extractionThe reaction mixture was extracted once with ethyl acetate
  2. extractionwas extracted four times with dichloromethane
  3. dry with materialThe combined organic layers were dried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-a5cec3f4efc542149a665df621b6bfc5
Source dataset
uspto-grants-2003_07
Patent number
US06596773B2

Reaction notes

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