反应详情

温度

90 °C

To a mixture of 2-phenylbenzimidazole (1.02 g, 5.25 mmol) in DMC (10 mL), DBU (0.80 g, 5.25 mmol) was added and the resulting mixture was heated to reflux (90° C.) for 6 hours. The solvent was evaporated under vacuum and the resulting oil was dissolved in methylene chloride (2 mL) and filtered through silica gel (2:1 EtOA/hexane). The solvent was evaporated under vacuum to afford 1-methyl-2-phenylbenzimidazole as a solid. The yield of 1-methyl-2-phenylbenzimidazole as determined by HPLC analysis was 98%.

1. additionwas added
2. temperaturethe resulting mixture was heated
3. customThe solvent was evaporated under vacuum
4. dissolutionthe resulting oil was dissolved in methylene chloride (2 mL)
5. filtrationfiltered through silica gel (2:1 EtOA/hexane)
6. customThe solvent was evaporated under vacuum