Formamide → 8-Methylquinazolin-4(1H)-one

HRID 1358727Notes

Reaction equation

HRID 1358727 reaction equation
[NH2:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>O>[CH3:11][C:10]1[CH:9]=[CH:8][CH:7]=[C:3]2[C:2]=1[N:1]=[CH:12][NH:14][C:4]2=[O:5]

Participants

4

Reactant 2

HCID 713FormamideHCID 781012-Amino-3-methylbenzoic acid

Product 1

HCID 1354713008-Methylquinazolin-4(1H)-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6 g of 2-amino 3 methyl benzoic acid and 8 ml formamide were heated at 170° C. for 1.5 hours. Water was added and solid filtered to provide 4.6 g of 8-methyl 4-quinazolinone as a white solid, mp-260° C. NMR acetone d6 δ 8.14 (1H, br, S), 8.06 (1H, m), 7.66 (1H, m), 7.38 (1H, m), 2.58 (3H, S).

Workup

  1. filtrationsolid filtered

Sources & evidence

ORD record
ord-7c7927668fbe4e6d8160274ac7e8d855
Source dataset
uspto-grants-2003_07
Patent number
US06596878B2

Reaction notes

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