HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 8-Methylquinazolin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 2-Amino-3-methylbenzoic acid | HCID 78101 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-Methylquinazolin-4(1H)-one | HCID 135471300 | — |
Reaction Steps
6 g of 2-amino 3 methyl benzoic acid and 8 ml formamide were heated at 170° C. for 1.5 hours. Water was added and solid filtered to provide 4.6 g of 8-methyl 4-quinazolinone as a white solid, mp-260° C. NMR acetone d6 δ 8.14 (1H, br, S), 8.06 (1H, m), 7.66 (1H, m), 7.38 (1H, m), 2.58 (3H, S).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06596878B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-7c7927668fbe4e6d8160274ac7e8d855 |
| Source note | uspto-grants-2003_07 |