Methyl 4-aminobenzoate → HCID 18185339, compound

HRID 1358773Notes

Reaction equation

HRID 1358773 reaction equation
[F:1][C:2]([F:20])([F:19])[S:3]([NH:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([C:16]([OH:18])=O)=[CH:10]2)(=[O:5])=[O:4].C[O:22][C:23](=[O:31])[C:24]1[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=1>>[F:1][C:2]([F:20])([F:19])[S:3]([NH:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([C:16]([NH:30][C:27]1[CH:28]=[CH:29][C:24]([C:23]([OH:31])=[O:22])=[CH:25][CH:26]=1)=[O:18])=[CH:10]2)(=[O:4])=[O:5]

Participants

3

Reactant 2

HCID 12082Methyl 4-aminobenzoateHCID 181852955-[[(Trifluoromethyl)sulfonyl]amino]-1H-indole-2-carboxylic acid

Product 1

HCID 18185339HCID 18185339, compound

Procedure

Same procedure as Example 82 except 5-Trifluoromethansulfonylamino-1H-Indole-2-Carboxylic Acid and 4-aminobenzoic methyl ester was used. 1H-NMR (400 MHz, DMSO-d6) δ 12.74 (s, 1H, COOH), 11.99 (d, J=1.2 Hz, 1H, NHCO), 11.61 (s, 1H, SNH), 10.54 (s, 1H, NH-1), 7.95 (m, 4H, ArH), 7.61 (d, J=2.1 Hz, 1H H-4), 7.50 (m, 2H, H-7 & H-3), 7.14 (dd, J=2, 9 Hz, 1H, H-6), MS m/z 426 (M−H).

Sources & evidence

ORD record
ord-4ddb50555103470da2a62b3a715fe611
Source dataset
uspto-grants-2003_07
Patent number
US06596772B1

Reaction notes

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