反应详情

To 50 ml of toluene was added 31 g (0.12 mol) of 4-(3,5-difluorophenyl)cyclohexanone monoethylene ketal obtained above and 76 g (1.7 mol) of formic acid, and the mixture was refluxed for 4 hours. The reaction solution was successively with water, a saturated aqueous sodium carbonate and water, dried over magnesium sulfate, and then the solvent was distilled off to afford 26 g of 4-(3,5-difluorophenyl)cyclohexanone.

1. temperaturethe mixture was refluxed for 4 hours
2. dry with materiala saturated aqueous sodium carbonate and water, dried over magnesium sulfate
3. distillationthe solvent was distilled off