HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 4-(3,5-Difluorophenyl)cyclohexan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 8-(3,5-Difluorophenyl)-1,4-dioxaspiro[4.5]decane | HCID 20610161 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(3,5-Difluorophenyl)cyclohexan-1-one | HCID 17790516 | 103.1% |
Reaction Steps
To 50 ml of toluene was added 31 g (0.12 mol) of 4-(3,5-difluorophenyl)cyclohexanone monoethylene ketal obtained above and 76 g (1.7 mol) of formic acid, and the mixture was refluxed for 4 hours. The reaction solution was successively with water, a saturated aqueous sodium carbonate and water, dried over magnesium sulfate, and then the solvent was distilled off to afford 26 g of 4-(3,5-difluorophenyl)cyclohexanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06599590B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-ba2d2734853346549731ca6397c247cd |
| Source note | uspto-grants-2003_07 |