Water → HCID 10130162, compound

HRID 1358907Notes

Reaction equation

HRID 1358907 reaction equation
S(=O)(=O)(O)O.[F:6][C:7]([F:15])([F:14])[C:8]([OH:13])([CH2:11][CH3:12])[C:9]#[N:10].[OH2:16]>C(OCC)C>[F:6][C:7]([F:15])([F:14])[C:8]([OH:13])([CH2:11][CH3:12])[C:9]([NH2:10])=[O:16]

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 27770732-Hydroxy-2-(trifluoromethyl)butanenitrile

Product 1

HCID 10130162HCID 10130162, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
115 °C

Procedure

Concentrated sulfuric acid (15.3 g) was added, under an argon atmosphere, to a 100 ml flask and the starting compound 3,3,3-trifluoro-2-hydroxy-2-ethylpropiononitrile (Fluorchem) (8 g) was then added dropwise. The reaction mixture was heated at 115° C. for 15 min and then cooled down to 8° C.; distilled water (21.8 g) was then added slowly. Diethyl ether was then added and the whole was stirred for 20 min.

Workup

  1. temperaturecooled down to 8° C.

Sources & evidence

ORD record
ord-3809d79d531d453494094b09498e274f
Source dataset
uspto-grants-2003_07
Patent number
US06599721B2

Reaction notes

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