Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-Hydroxy-2-(trifluoromethyl)butanenitrile | HCID 2777073 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 10130162 | HCID 10130162 | — |
Reaction Steps
Concentrated sulfuric acid (15.3 g) was added, under an argon atmosphere, to a 100 ml flask and the starting compound 3,3,3-trifluoro-2-hydroxy-2-ethylpropiononitrile (Fluorchem) (8 g) was then added dropwise. The reaction mixture was heated at 115° C. for 15 min and then cooled down to 8° C.; distilled water (21.8 g) was then added slowly. Diethyl ether was then added and the whole was stirred for 20 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06599721B2 |
|---|
| Source dataset | uspto-grants-2003_07 |
|---|
| ORD ID | ord-3809d79d531d453494094b09498e274f |
|---|
| Source note | uspto-grants-2003_07 |
|---|
