HCID 18180103, compound → HCID 17896794, compound

HRID 1358934Notes

Reaction equation

HRID 1358934 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][N:9]([C:12]3[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:13]=3[O:21][CH3:22])[CH2:8][CH2:7]2)=[O:5])[CH2:3][CH2:2]1>C(O)C.[Pd]>[NH2:18][C:16]1[CH:15]=[CH:14][C:13]([O:21][CH3:22])=[C:12]([N:9]2[CH2:10][CH2:11][N:6]([C:4]([CH:1]3[CH2:3][CH2:2]3)=[O:5])[CH2:7][CH2:8]2)[CH:17]=1

Participants

4

Reactant 1

HCID 18180103HCID 18180103, compound

Product 1

HCID 17896794HCID 17896794, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of the cyclopropyl-[4-(2-methoxy-5-nitrophenyl)-piperazin-1-yl]methanone (D17) (1.8 mmol) in ethanol was hydrogenated over 10% Palladium on charcoal catalyst for 2 hrs at room temperature to give the title compound in 91% yield. Found MH+ 276.

Sources & evidence

ORD record
ord-597062c2af9a4eb495e5b05f406ab81b
Source dataset
uspto-grants-2003_07
Patent number
US06599904B2

Reaction notes

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