反应详情

A solution of thiophene-2-sulfonyl chloride (82 mg;0.45 mmol) in acetone (2 ml) was added to a solution of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline (100 mg;0.45 mmol) in acetone (2 ml) and the mixture stood overnight at room temperature. The resultant crystalline solid was filtered off and washed with acetone, then diethyl ether, to afford the title compound as the hydrochloride salt. (153 mg;84%). MS: m/z=368.

1. filtrationThe resultant crystalline solid was filtered off
2. washwashed with acetone