5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 18180134, compound

HRID 1358962Notes

Reaction equation

HRID 1358962 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:10]1[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH:15]=1.[Cl:17][C:18]1[CH:31]=[CH:30][C:21]2[S:22][C:23]([S:26](Cl)(=[O:28])=[O:27])=[C:24]([CH3:25])[C:20]=2[CH:19]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][S:26]([C:23]2[S:22][C:21]3[CH:30]=[CH:31][C:18]([Cl:17])=[CH:19][C:20]=3[C:24]=2[CH3:25])(=[O:28])=[O:27])=[CH:5][C:4]=1[C:10]1[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH:11]=1

Participants

3

Reactant 2

HCID 27357565-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chlorideHCID 18180121HCID 18180121, compound

Product 1

HCID 18180134HCID 18180134, compound

Procedure

The title compound (E130) was prepared from 4-methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenylamine (free base of D39) (100 mg, 0.46 mmol) and 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (129 mg, 0.46 mmol) using the method of Example 1 (177 mg, 77%). MH+=463/465.

Sources & evidence

ORD record
ord-2c9e544f88dc4d3db26089e0d520ee28
Source dataset
uspto-grants-2003_07
Patent number
US06599904B2

Reaction notes

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