反应详情

2-Amino-6-chloro-3-(2,3,5-trichlorophenyl)pyrazine (0.215 g, 7.0×10−3 mole) Example 1 Route A and 1-methylpiperazine (5 ml, Aldrich), were heated at 140° C. for 1 hr. The mixture was evaporated in vacuo and the residue was purified by ‘flash chromatography’ eluting with ethanol:dichloromethane, 0-4%. The product was dissolved in the minimum of dichloromethane and hexane (10 ml), added slowly to give yellow needles. Yield 0.247 g (95%), M.p. 185° C.

1. customThe mixture was evaporated in vacuo
2. customthe residue was purified by ‘flash chromatography’
3. washeluting with ethanol
4. dissolutionThe product was dissolved in the minimum of dichloromethane and hexane (10 ml)
5. additionadded slowly
6. customto give yellow needles