Cyclopropanecarbonyl chloride → HCID 18180198, compound

HRID 1358980Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([Cl:15])[C:9]=2[Cl:16])=[N:6][CH:5]=[C:4]([NH:17][C:18](=[O:20])[CH3:19])[N:3]=1.[CH:21]1([C:24](Cl)=[O:25])[CH2:23][CH2:22]1>>[CH:21]1([C:24]([NH:1][C:2]2[C:7]([C:8]3[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([Cl:15])[C:9]=3[Cl:16])=[N:6][CH:5]=[C:4]([NH:17][C:18](=[O:20])[CH3:19])[N:3]=2)=[O:25])[CH2:23][CH2:22]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 18180219HCID 18180219, compound

Product 1

HCID 18180198HCID 18180198, compound

Procedure

This compound was prepared in an analogous manner to Example 9 from 2-amino-6-acetamido-3-(2,3,5-trichlorophenyl)pyrazine (Example 1) and cyclopropylcarbonyl chloride (Aldrich). Yield 0.387 g (61%) N.m.r. (D6DMSO) δ: 0.53 (2H, m), 0.7 (2H, m), 1.75 (1H, m), 2.18 (3H, s), 7.43 (1H, d), 7.87 (1H, d), 9.22 (1H, s), 10.36 (1H, b), 10.83 (1H, b).

Sources & evidence

ORD record: ord-d5f287ebbb734fa99c3a0baf7a4ce83b
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06599905B2

Reaction notes

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