Ammonium Hydroxide → HCID 9840558, compound

HRID 1358987Notes

Reaction equation

HRID 1358987 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2C=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[N:11]=[C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[NH:9]2)[N:5]=[CH:4][N:3]=1.[NH4+:27].[OH-]>>[NH2:27][C:2]1[N:3]=[CH:4][N:5]=[C:6]([N:8]2[C:12]([C:14]3[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=3)=[N:11][C:10]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[N:9]2)[CH:7]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 18180292HCID 18180292, compound

Product 1

HCID 9840558HCID 9840558, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 1-(4-chloropyrimidin-6-yl)-3-phenyl-5-(4-fluorophenyl)-1,2,4-triazine (0.080 g, 0.23 mmol) and concentrated NH4OH was heated to 120° C. for 18 h in a sealed reaction vessel. After cooling the reaction to ambient temperature, the precipitate which had formed was collected and washed with water, air-dried and dried in vacuo at 40° C. to afford the title compound as a white solid; yield 0.030 g (39%): ES MS m/z=333 (MH+).

Workup

  1. temperatureAfter cooling
  2. customthe reaction to ambient temperature
  3. customthe precipitate which had formed
  4. customwas collected
  5. washwashed with water
  6. customair-dried
  7. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-77e1cf3b919e4b23858a8eb497d5f74b
Source dataset
uspto-grants-2003_07
Patent number
US06599910B1

Reaction notes

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