反应详情

To a solution of 1.48 g (3 mmol) {4-[2-amino-1-(3-chloro-phenyl)-ethyl]-4-hydroxy-piperidin-1-yl}-(3,5-bis-trifluoromethyl-phenyl)-methanone in 30 ml of tetrahydrofuran 1.46 g (9 mmol)1,1′-carbonyl-diimidazole was added and the mixture was stirred over night at room temperature under argon. Water (15 ml) was added, the organic layer was separated, washed twice with a solution of hydrochloric acid (1 M), dried and evaporated. The residue was purified by flash column chromatography (SiO2, ethyl acetate) to yield 1.08 g (69%) of the title compound.

1. customthe organic layer was separated
2. washwashed twice with a solution of hydrochloric acid (1 M)
3. customdried
4. customevaporated
5. customThe residue was purified by flash column chromatography (SiO2, ethyl acetate)