反应详情

Following the procedure described in Method B, Step 5 of Example 1, the title compound was prepared from 6-(3-pentyl-benzofuran-2-yl)-naphthalen-2-ol (0.33 g, 1 mmol), cesium carbonate (0.75 g, 2.3 mmol), ethyl bromoacetate (0.16 mL, 1.4 mmol) in acetone (20 mL). Crystallization from hexane furnished the title compound as a white solid (0.39 g), mp 84-86° C. Mass spectrum (+APCl, [M+H]+) m/z 417. 1HNMR (300 MHz, DMSO-d6): δ8.25 (s, 1H), 8.00 (d, 1H, J=9.1 Hz), 7.94-7.84 (m, 2H), 7.69-7.66 (m, 1H), 7.60 (d, 1H, J=7.5 Hz), 7.35-7.25 (m, 4H), 4.93 (s, 2H), 4.20 (q, 2H, J=7.1 Hz), 2.98 (t, 2H, J=7.3 Hz), 1.72 (p, 2H, J=7.3 Hz), 1.43-1.28 (m, 4H), 1.23 (t, 3H, J=7.2 Hz), and 0.83 ppm (t, 3H, J=7.1 Hz). Elemental Analysis for C27H28O4.0.5H2O: Calculated: C, 76.21; H, 6.87; N, 0.00. Found: C, 76.48; H, 6.69; N, 0.12.

1. customCrystallization from hexane