2,6-Dibromopyridine → 2-Bromo-6-methoxypyridine

Temperature

80 °C

250 ml of 28% sodium methoxide methanol solution was added dropwise into a mixture of 200 g of 2,6-dibromopyridine and 150 ml of methanol while heating at 80° C. stirring in an oil bath, followed by stirring under heating for 2 hours as it was. After cooling as it was, the mixture was extracted with diethyl ether-water, and the organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and the solvent was removed, to give 150 g of the target compound.

1. stirringby stirring
2. temperatureunder heating for 2 hours as it
3. temperatureAfter cooling as it
4. extractionthe mixture was extracted with diethyl ether-water
5. washthe organic phase was washed with water and brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customthe solvent was removed

ORD record

ord-19ae1b4156a448a0ab5bd25fbab2cc5b

Source dataset

uspto-grants-2003_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06599917B1