L-Tartaric acid → HCID 87932086, compound

HRID 1359286Notes

Reaction equation

HRID 1359286 reaction equation
[C:1]([C:3]1([OH:11])[CH:8]2[CH2:9][CH2:10][N:5]([CH2:6][CH2:7]2)[CH2:4]1)#[CH:2].[C:12]([OH:21])(=[O:20])[C@@H:13]([C@H:15]([C:17]([OH:19])=[O:18])[OH:16])[OH:14]>CO>[C:1]([C@:3]1([OH:11])[CH:8]2[CH2:9][CH2:10][N:5]([CH2:6][CH2:7]2)[CH2:4]1)#[CH:2].[C:12]([OH:21])(=[O:20])[C@@H:13]([C@H:15]([C:17]([OH:19])=[O:18])[OH:16])[OH:14]

Participants

4

Reactant 2

HCID 444305L-Tartaric acidHCID 36135173-Ethynyl-1-azabicyclo[2.2.2]octan-3-ol

Product 1

HCID 87932086HCID 87932086, compoundYield 6.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

15.1 g of 3-ethynyl-3-quinuclidinol and 15 g of L-(+)-tartaric acid were dissolved under heating in 300 ml of methanol. After cooling as it was, the resulting crystals were collected by filtration and recrystallized from methanol three times, to give 2.07 g of the title compound.

Workup

  1. temperatureAfter cooling as it
  2. filtrationthe resulting crystals were collected by filtration
  3. customrecrystallized from methanol three times

Sources & evidence

ORD record
ord-47e2ea67f7124980bcf2a2abd509b690
Source dataset
uspto-grants-2003_07
Patent number
US06599917B1

Reaction notes

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