HCID 18182251, compound → HCID 18182255, compound

HRID 1359311Notes

Reaction equation

HRID 1359311 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([CH:10]([OH:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1>O1CCCC1.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10](=[O:17])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 18182251HCID 18182251, compound

Product 1

HCID 18182255HCID 18182255, compoundYield 98.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

36.0 g of manganese(IV) oxide was added to a solution of 3.7 g of 6-chloro-3-(α-hydroxybenzyl)-2-methoxypyridine in 80 ml of tetrahydrofuran, followed by stirring at room temperature for 2 hours. Insoluble matters were filtered off and then the solvent was evaporated, to give 3.6 g of the title compound.

Workup

  1. filtrationInsoluble matters were filtered off
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-a0a40f9f7df54f5e864a8c7fcbd00206
Source dataset
uspto-grants-2003_07
Patent number
US06599917B1

Reaction notes

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