反应详情

A 1.09 mol tetrahydrofuran solution containing benzylmagnesium chloride was slowly added dropwise into a mixture of 1 g of 2-bromo-6-(2-ethoxyethyl)oxypyridine, 145 mg of 1,3-bis(diphenylphosphino)propanenickel(II) chloride and 5 ml of tetrahydrofuran with stirring under ice-cooling in a nitrogen atmosphere. After stirring for 2.5 hours, an aqueous saturated ammonium chloride solution was added thereto and the mixture was extracted with ethyl acetate. The organic phase was further washed with brine, dried over anhydrous sodium sulfate and the solvent was removed. The residue was subjected to silica gel column chromatography using 5% ethyl acetate/hexane as an eluent for separation and purification, to give 1 g of the target compound.

1. temperaturecooling in a nitrogen atmosphere
2. stirringAfter stirring for 2.5 hours
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic phase was further washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customthe solvent was removed
7. customfor separation and purification