反应详情

20.4 ml of a Jone's reagent was slowly added dropwise into 200 ml of an acetone solution containing 5.1 g of 1-methoxy-3-phenyl-2-propanol. After stirring for 30 minutes at room temperature, 30 ml of 2-propanol was slowly added to the reaction solution. After removing the solvent, water was added thereto and the mixture was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed. The residue was subjected to silica gel column chromatography and elute with hexane/ethyl acetate (6:1), to give 3.7 g of the target compound.

1. customAfter removing the solvent, water
2. additionwas added
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic phase was washed with brine
5. customthe solvent was removed
6. washelute with hexane/ethyl acetate (6:1)