Ammonia → HCID 10490451, compound

Participants

Reaction Conditions

Reaction Steps

The above pyrrolopyrimidine (1.3) (2.14 g, 7.5 mmol) was suspended in 20 ml methanol and 0.880 ammonia (10 ml) added and the solution stirred at 40° C. overnight. The solvent was removed and the product suspended in methanol and filtered to give a pale yellow solid. Yield 0.71 g. A further 1.05 g was isolated by concentration of the mother liquors. Overall yield 1.76 g, 96%. δH 2.52 (3H, s, SCH3), 2.91 (2H, t, J 7.1 Hz, OCH2CH2), 3.65 (2H, t, J 6.9 Hz, OCH2), 4.68 (1H, t, OH), 7.27 (1H, s, H6), 12.12 (1H, s, NH) ppm.

Provenance & Evidence