Thionyl Chloride → HCID 22145275, compound

HRID 1359476Notes

Reaction equation

HRID 1359476 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([OH:13])=O)[CH3:2].S(Cl)([Cl:16])=O>C1(C)C=CC=CC=1>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([Cl:16])=[O:13])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 251958129075-84-9

Product 1

HCID 22145275HCID 22145275, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 3-(2-ethylphenyl)propanoic acid (prepared in 3 steps from 1-ethyl-2-iodobenzene, 4.24 g, 23.8 mmole), thionyl chloride (9.50 ml, 130 mmol) and toluene (100 ml) was refluxed for 2 hours. Concentration in vacuo gave 3-(2-ethylphenyl)propanoyl chloride which was taken up in methylene chloride and used in the next step as a crude.

Workup

  1. temperaturewas refluxed for 2 hours
  2. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-5c1cb8e628a940c689106472e574419d
Source dataset
uspto-grants-2003_07
Patent number
US06600015B2

Reaction notes

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