反应详情

A mixture of 8.0 g (28 mmol) of 3-[2-(4-(methylthio)phenyl)-2-cyanoacetyl](6-methyl)pyridine, 20 ml of acetic acid and 60 ml of concentrated hydrochloric acid was heated at 95° C. to 100° C. for 1.5 h. The orange solution was cooled and adjusted to pH 10 using concentrated ammonia solution. The resulting yellow-beige suspension was filtered and the residue was washed with water and dried. This gave 5.35 g (74.3) of the title product in the form of a yellow solid.

1. temperaturewas heated at 95° C. to 100° C. for 1.5 h
2. temperatureThe orange solution was cooled
3. filtrationThe resulting yellow-beige suspension was filtered
4. washthe residue was washed with water
5. customdried