Trifluoroacetic acid → HCID 22482749, compound

HRID 1359492Notes

Reaction equation

HRID 1359492 reaction equation
C(OC([N:8]1[CH2:13][C:12]([C:14](=[O:16])[NH2:15])=[CH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>C(Cl)(Cl)Cl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[C:14]([C:12]1[CH2:13][NH:8][CH2:9][CH2:10][CH:11]=1)(=[O:16])[NH2:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22482765HCID 22482765, compound

Product 1

HCID 22482749HCID 22482749, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In 4.0 ml of chloroform, 1.1 g of 1-tert-butoxycarbonyl-5-carbamoyl-1,2,3,6-tetrahydropyridine was dissolved, and 4.0 ml of trifluoroacetic acid was added thereto. The reaction mixture was stirred for 30 minutes at room temperature, and was subsequently concentrated under reduced pressure to yield 1.4 g of crude 5-carbamoyl-1,2,3,6-tetrahydropyridine trifluoroacetate in the form of amorphous.

Workup

  1. concentrationwas subsequently concentrated under reduced pressure

Sources & evidence

ORD record
ord-0f00ba682ef242a88fab5ca72a1971f1
Source dataset
uspto-grants-2003_07
Patent number
US06600038B1

Reaction notes

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