HCID 22482760, compound → HCID 12069438, compound

HRID 1359493Notes

Reaction equation

HRID 1359493 reaction equation
Cl.[C:2]([C:5]1[CH2:10][NH:9][CH2:8][CH2:7][CH:6]=1)(=[O:4])[NH2:3]>C(=O)([O-])O.[Na+]>[C:2]([C:5]1[CH2:10][NH:9][CH2:8][CH2:7][CH:6]=1)(=[O:4])[NH2:3]

Participants

3

Reactant 1

HCID 22482760HCID 22482760, compound

Product 1

HCID 12069438HCID 12069438, compound

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

5-carbamoyl-1,2,3,6-tetrahydropyridine hydrochloride was dissolved in a saturated aqueous solution of sodium hydrogen carbonate, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate. After the desiccant was filtered off, the filtrate was concentrated under reduced pressure to yield crystals of free 5-carbamoyl-1,2,3,6-tetrahydropyridine.

Workup

  1. extractionfollowed by extraction with chloroform
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. filtrationAfter the desiccant was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5ab469db5722433689489ed1de3e8560
Source dataset
uspto-grants-2003_07
Patent number
US06600038B1

Reaction notes

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