1-Methylpiperazine → HCID 22561769, compound

HRID 1359689Notes

Reaction equation

HRID 1359689 reaction equation
[CH:1]([C:3]1[NH:7][C:6]([CH3:8])=[C:5]([CH2:9][CH2:10][C:11]([OH:13])=O)[C:4]=1[CH3:14])=[O:2].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[CH3:14][C:4]1[C:5]([CH2:9][CH2:10][C:11]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[O:13])=[C:6]([CH3:8])[NH:7][C:3]=1[CH:1]=[O:2]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 15125203-(5-formyl-2,4-dimethyl-1H-pyrrol-3-yl)propanoic Acid

Product 1

HCID 22561769HCID 22561769, compoundYield 72.1%

Procedure

3-(5-Formyl-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid (1.37 g, 6.50 mmol) reacted with 1-methylpiperazine (719.6 mg, 7.15 mmol) to give 1.3 g (72%) of 3,5-dimethyl-4-[3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-1H-pyrrole-2-carbaldehyde.

Sources & evidence

ORD record
ord-93b90888b9cc4fe190b723a24b860200
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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