5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one → 5-(2,6-Dichloro-phenylmethanesulfonyl)-3-[1-(3,5-dimethyl-4-morpholin-4-ylmethyl-1h-pyrrol-2-yl)-meth-(z)-ylidene]-1,3-dihydro-indol-2-one

HRID 1359696ノート

反応式

HRID 1359696 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[CH3:23][C:24]1[C:28]([CH2:29][N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[C:27]([CH3:36])[NH:26][C:25]=1[CH:37]=O>>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:37]\[C:25]1[NH:26][C:27]([CH3:36])=[C:28]([CH2:29][N:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)[C:24]=1[CH3:23])(=[O:12])=[O:11]

参加物

3

反応物 2

HCID 181797685-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-oneHCID 220597173,5-dimethyl-4-morpholin-4-ylmethyl-1H-pyrrole-2-carbaldehyde

生成物 1

HCID 590776175-(2,6-Dichloro-phenylmethanesulfonyl)-3-[1-(3,5-dimethyl-4-morpholin-4-ylmethyl-1h-pyrrol-2-yl)-meth-(z)-ylidene]-1,3-dihydro-indol-2-one

実験手順

5-(2,6-Dichlorophenylmethanesulfonyl)-1,3-dihydro-indol-2-one was condensed with 3,5-dimethyl-4-morpholin-4-ylmethyl-1H-pyrrole-2-carbaldehyde to give 2.0 g of the titled compound as an orange solid.

出典と根拠

ORDレコード
ord-b5ee9c0f28ad48289721a2d61288b607
出典データセット
uspto-grants-2003_07
特許番号
US06599902B2

反応ノート

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