(S)-2-cyclopropylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester → (2S)-N-Cyclopropylpyrrolidine-2-carboxamide

HRID 1359747Notes

Reaction equation

HRID 1359747 reaction equation
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[C:16](=[O:21])[NH:17][CH:18]1[CH2:20][CH2:19]1)=O)C1C=CC=CC=1>[Pd]>[CH:18]1([NH:17][C:16]([C@@H:12]2[CH2:13][CH2:14][CH2:15][NH:11]2)=[O:21])[CH2:20][CH2:19]1

Participants

3

Reactant 1

HCID 69997288(S)-2-cyclopropylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester

Product 1

HCID 22691330(2S)-N-Cyclopropylpyrrolidine-2-carboxamide

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

(S)-2-cyclopropylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester (907 mg, 3.14 mmol) was hydrogenated using Pd/C (5%, 61 mg) to give (S)-pyrrolidine-2-carboxylic acid cyclopropylamide.

Sources & evidence

ORD record
ord-33741e3476b649c0ba109edaa47a2e26
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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