HRID1359765

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21139221

未命名化合物

结构：Cc1[nH]c(C=O)c(C)c1C(=O)N1CCC[C@H]1CNC1CC1

HCID86588615

未命名化合物

PRODUCTS

生成物

$结构：Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4ccccc4)cc32)c(C)c1C(=O)N1CCC[C@H]1CNC1CC1$

HCID59077598

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID8082

Piperidine

C5H11N

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one (27 mg), 4-((S)-2-cyclopropylaminomethyl-pyrrolidine-1-carbonyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (25 mg) and piperidine (1 drop) in ethanol (2mL) was stirred at rt for 4 hours, the precipitate was collected by vacuum filtration and purified on a silica gel column to give the titled compound.

WORKUP

后处理

filtrationthe precipitate was collected by vacuum filtration
custompurified on a silica gel column

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4565b3f73f554e029e528e873120c52a
来源数据集: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06599902B2
来源说明: uspto-grants-2003_07

反应 SMILES

[C:1]1([CH2:7][S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:21]1([NH:24][CH2:25][C@@H:26]2[CH2:30][CH2:29][CH2:28][N:27]2[C:31]([C:33]2[C:34]([CH3:41])=[C:35]([CH:39]=O)[NH:36][C:37]=2[CH3:38])=[O:32])[CH2:23][CH2:22]1>N1CCCCC1.C(O)C>[CH:21]1([NH:24][CH2:25][C@@H:26]2[CH2:30][CH2:29][CH2:28][N:27]2[C:31]([C:33]2[C:34]([CH3:41])=[C:35](/[CH:39]=[C:14]3\[C:15](=[O:20])[NH:16][C:17]4[C:13]\3=[CH:12][C:11]([S:8]([CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)(=[O:10])=[O:9])=[CH:19][CH:18]=4)[NH:36][C:37]=2[CH3:38])=[O:32])[CH2:22][CH2:23]1