HRID1359775

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID253298

2-Furanmethanamine, tetrahydro-

C5H11NO

$结构：Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)On1nnc2cccnc21$

HCID137178925

未命名化合物

PRODUCTS

生成物

$结构：Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)NCC1CCCO1$

HCID59077639

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

To a solution of 5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid [1,2,3]triazolo[4,5-b]pyridin-3-yl ester (100 mg, 0.162 mmol) in DMA (2 mL) was added C-(tetrahydro-furan-2-yl)-methylamine (32 mg, 2 eq.). The mixture was stirred at rt for 18 hours. The reaction was concentrated, diluted with DCM, washed with sat.NaHCO3 and water, concentrated and triturated with methanol to give the titled compound as a yellow solid.

WORKUP

后处理

concentrationThe reaction was concentrated
additiondiluted with DCM
washwashed
concentrationNaHCO3 and water, concentrated
customtriturated with methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-400ee670833f40c29bf11a97d45a8b4d
来源数据集: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06599902B2
来源说明: uspto-grants-2003_07

反应 SMILES

N1C2C(=NC=CC=2)N([O:10][C:11]([C:13]2[C:17]([CH3:18])=[C:16](/[CH:19]=[C:20]3\[C:21](=[O:41])[NH:22][C:23]4[C:28]\3=[CH:27][C:26]([S:29]([CH2:32][C:33]3[C:38]([Cl:39])=[CH:37][CH:36]=[CH:35][C:34]=3[Cl:40])(=[O:31])=[O:30])=[CH:25][CH:24]=4)[NH:15][C:14]=2[CH3:42])=O)N=1.[O:43]1[CH2:47][CH2:46][CH2:45][CH:44]1[CH2:48][NH2:49]>CC(N(C)C)=O>[O:43]1[CH2:47][CH2:46][CH2:45][CH:44]1[CH2:48][NH:49][C:11]([C:13]1[C:17]([CH3:18])=[C:16](/[CH:19]=[C:20]2\[C:21](=[O:41])[NH:22][C:23]3[C:28]\2=[CH:27][C:26]([S:29]([CH2:32][C:33]2[C:38]([Cl:39])=[CH:37][CH:36]=[CH:35][C:34]=2[Cl:40])(=[O:30])=[O:31])=[CH:25][CH:24]=3)[NH:15][C:14]=1[CH3:42])=[O:10]