5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one → HCID 59077603, compound

HRID 1359788Notes

Reaction equation

HRID 1359788 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[CH3:23][C@H:24]1[NH:29][C@@H:28]([CH3:30])[CH2:27][N:26]([CH2:31][C:32]2[C:33]([CH3:40])=[C:34]([CH:38]=O)[NH:35][C:36]=2[CH3:37])[CH2:25]1>C(O)C.N1CCCCC1>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:38]\[C:34]1[NH:35][C:36]([CH3:37])=[C:32]([CH2:31][N:26]2[CH2:25][C@H:24]([CH3:23])[NH:29][C@H:28]([CH3:30])[CH2:27]2)[C:33]=1[CH3:40])(=[O:12])=[O:11]

Participants

5

Reactant 2

HCID 181797685-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-oneHCID 88094320HCID 88094320, compound

Product 1

HCID 59077603HCID 59077603, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8082PiperidineSolvent

Procedure

5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one was condensed with 4-((3R,5S)-3,5-dimethyl-piperazin-1-ylmethyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde in ethanol and piperidine to give the tiled compound.

Workup

  1. customto give the tiled compound

Sources & evidence

ORD record
ord-f54bfcc5db1144ba96ad541aa07b0e41
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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