5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one → HCID 59077679, compound

HRID 1359797Notes

Reaction equation

HRID 1359797 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[CH:23]1([CH2:26][N:27]2[CH2:32][CH2:31][N:30]([CH2:33][C:34]3[C:35]([CH3:42])=[C:36]([CH:40]=O)[NH:37][C:38]=3[CH3:39])[CH2:29][CH2:28]2)[CH2:25][CH2:24]1>C(O)C.N1CCCCC1>[CH:23]1([CH2:26][N:27]2[CH2:32][CH2:31][N:30]([CH2:33][C:34]3[C:35]([CH3:42])=[C:36](/[CH:40]=[C:16]4\[C:17](=[O:22])[NH:18][C:19]5[C:15]\4=[CH:14][C:13]([S:10]([CH2:9][C:3]4[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=4[Cl:8])(=[O:12])=[O:11])=[CH:21][CH:20]=5)[NH:37][C:38]=3[CH3:39])[CH2:29][CH2:28]2)[CH2:25][CH2:24]1

Participants

5

Reactant 2

HCID 181797685-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-oneHCID 18179943HCID 18179943, compound

Product 1

HCID 59077679HCID 59077679, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8082PiperidineSolvent

Procedure

5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one was condensed with 4-(4-cyclopropylmethyl-piperazin-1-ylmethyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde in ethanol and piperidine to give the titled compound. MS m/z 613 [M−1].

Sources & evidence

ORD record
ord-c64c3718c078401e93d246eb0782b616
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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